When was the lipid hypothesis

This "lipid hypothesis of cold tolerance" is less well supported in animals. In fruit flies, cold acclimation does not coincide with a reduced amount of saturated fatty acids, [40] and recent genetic studies on a nematode indicate that the mechanisms involved in cold adaptation in animals may be different from those in plants and microbes.

Template:WikiDoc Sources. In: Gesammelte Abhandlungen zur wissenschaftlichen Medizin. Germany: Staatsdruckerei Frankfurt. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy". Lipid Res. PMID Zentralbl Allg Pathol. Beitr Pathol Anat. Am J Med. Eat Well and Stay Well.

United States: Doubleday. ISBN The American Physiological Society. Nutr Metab. J Lipid Res. Why did it take so long? Adv Nurse Pract. Nature Medicine. Curr Atheroscler Rep. United States: New Trends Publishing. The International Network of Cholesterol Skeptics. Clinical trials". Select Format Select format. Permissions Icon Permissions. Abstract The Lipid Hypothesis, which states that lowering blood cholesterol levels should significantly reduce the incidence of coronary heart disease CHD , has been repeatedly tested in primary and secondary intervention trials.

Issue Section:. You do not currently have access to this article. Download all slides. Sign in Don't already have an Oxford Academic account? You could not be signed in. Sign In Forgot password? Don't have an account? European Society of Cardiology members Sign in via society site. Sign in via your Institution Sign in. Purchase Subscription prices and ordering for this journal Short-term Access To purchase short term access, please sign in to your Oxford Academic account above.

This article is also available for rental through DeepDyve. View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic.

More on this topic Lipoproteins and coronary heart disease in the Helsinki Heart Study. Cholesterol and Recurrent Events Trial investigators. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study CARDS : Multicentre randomised placebo-controlled trial. Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease.

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: The IDEAL study: A randomized controlled trial.

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: A randomized controlled trial.

Canadian Cardiovascular Society position statement—recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease.

Can J Cardiol ; National Cholesterol Education Program. European guidelines on cardiovascular disease prevention in clinical practice: Executive summary. Ear Heart J ; Progression of coronary artery disease predicts clinical coronary events. Long-term follow-up from the Cholesterol Lowering Atherosclerosis Study. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. Simvastatin with or without ezetimibe in familial hypercholesterolemia.

N Engl J Med. NEJM ; Effects of torcetrapib in patients at high risk for coronary events. Preventing cardiovascular disease among Canadians: What are the potential benefits of treating hypertension or dyslipidemia? In memoriam We are saddened by the passing of cardiology fellow Dr Aneez Mohamed, whose life was tragically cut short in a hit and run accident on 7 February His in memoriam appears on page Dr Andrade is a cardiology fellow at the University of British Columbia.

Dr Frohlich is a professor of pathology and laboratory medicine at UBC. He is also a founding director of the Lipid Clinic at St. Dr Ignaszewski is head of the Division of Cardiology at St. He is also a clinical professor of medicine at UBC. Above is the information needed to cite this article in your paper or presentation. Solid-organ transplantation in HIV-infected patients. The ICMJE is small group of editors of general medical journals who first met informally in Vancouver, British Columbia, in to establish guidelines for the format of manuscripts submitted to their journals.

The group became known as the Vancouver Group. Its requirements for manuscripts, including formats for bibliographic references developed by the U. An alternate version of ICMJE style is to additionally list the month an issue number, but since most journals use continuous pagination, the shorter form provides sufficient information to locate the reference. The NLM now lists all authors. Skip to main content. Issue: BCMJ, vol. The early intervention studies In the late s the realization grew that prevention programs could not rely solely on protecting the most susceptible but must protect the entire population.

The statin era The mids saw the emergence of mega-trials using lipid-lowering therapy with HMG-CoA reductase inhibitors statins. Current guidelines Owing to the demonstrated benefits of intensive lipid-lowering therapy, most major lipid guidelines were revised between and see Table.

Therapy for difficult-to-control lipid levels As discussed, statins have been shown to be safe and effective at lowering lipid levels especially LDL-C and protecting against CVD.

Conclusions Over the past 50 years the lipid hypothesis has grown from an obscure theory to a central concept in the practice of cardiovascular medicine and the prevention of heart disease. Competing interests None declared. References 1.